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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 5, No. 4, 2007, pp. 137-150
Bioline Code: rm07029
Full paper language: English
Document type: Review Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 5, No. 4, 2007, pp. 137-150

 en Human sperm DNA damage in the context of assisted reproductive techniques
Youssry, Mohamed; Ozmen, Batuhan; Orief, Yasser; Zohni, Khaled & Al-Hasani, Safaa

Abstract

Fertilization involves direct interaction of the sperm andoocyte, fusion of the cell membranes and union of male and femalegamete genomes. The completion of this process and subsequentembryo development depend in part on the inherent integrityof the sperm DNA. Sperm genomequality has been emphasized for several years as playing a majorrole in early embryogenesis. There is clinical evidence showing that human sperm DNA damage may adversely affectreproductive outcomes and that spermatozoa of infertile menpossess substantially more DNA damage than do spermatozoa offertile men. Testing DNA integrity may help selecting spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted reproductive techniques (ARTs). This review will focus onhow sperm DNA is organized, what causes sperm DNA damage and whatimpact this damage may have on reproductive outcome.

Keywords
Fertilization, Sperm DNA damage, Assisted reproductive technique (ART).

 
© Copyright 2007 - Iranian Journal of Reproductive Medicine
Alternative site location: http://www.ijrm.ir

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