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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 6, No. 3, 2008, pp. 149-155
Bioline Code: rm08024
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 6, No. 3, 2008, pp. 149-155

 en Effect of Cnidoscolous aconitifolius check for this species in other resources (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats
Yakubu, Musa Toyin; Akanji, Musbau Adewumi; Oladiji, Adenike Temidayo; Olatinwo, Abdul Waheed Olajide; Adesokan, Abdulfatai Ayoade; Yakubu, Monsurat Oyenike; Owoyele, Bamidele Victor; Sunmonu, Taofik Olatunde & Ajao, Moyosore Salihu

Abstract

Background: The increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials.
Objective: The effect of administration of aqueous extract of Cnidoscolous aconitifolius check for this species in other resources leaves for seven days on reproductive hormones of female Wistar rats was investigated.
Materials and Methods: Sixty female albino rats were grouped into four (A, B, C and D) of 15 each. Group A (the control) received orally 6.5 ml kg-1 body weight of distilled water on daily basis for 7 days. Groups B, C and D were treated like the control except that they received 250, 500 and 1000 mg kg-1 body weight of the extract.
Results: Phytochemical screening of the extract revealed the presence of alkaloids, saponins, phenolics, tannins, flavonoids, anthraquinones, phlobatannins and triterpenes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin concentration whereas those of estradiol, progesterone, follicle stimulating and luteinizing hormones were significantly reduced.
Conclusion: The alterations in the female rat reproductive hormones by the extract are indications of adverse effect on the maturation and ovulation of follicles. Consequently, the extract may impair fertility and conception in female rats. Thus, the Cnidoscolous aconitifolius leaf extract may be explored as a female contraceptive.

Keywords
Cnidoscolous aconitifolius, Prolactin, Follicle stimulating hormone, Luteinizing hormone, Estradiol, Progesterone, Fertility, Conception, Contraceptive.

 
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Alternative site location: http://www.ijrm.ir

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