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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 7, No. 2, 2009, pp. 79-84
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Bioline Code: rm09014
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 7, No. 2, 2009, pp. 79-84
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Results of ICSI in severe oligozoospermic and azoospermic patients with AZF microdeletions
Kilic, Sevtap; Yuksel, Beril; Yilmaz, Nafiye; Ozdemir, Erkan; Ozturk, Ufuk; Ceylaner, Serdar & Dogan, Muammer
Abstract
Background:
The aim of this study was to determine the incidence of AZF
(Azoospermia Factor) microdeletions of the Y chromosome in infertile Turkish male
patients and intracytoplasmic sperm injection (ICSI) outcome of these patients.
Objective:
This study was undertaken in order to evaluate the outcome of intracytoplasmic
sperm injection (ICSI) in infertil man with AZF microdeletions
Materials and Methods:
We evaluated 348 azoospermic and oligozoospermic patients
retrospectively. Fourty of these patients had various types of AZF microdeletions. These
patients had non-obstructive severe oligoasthenospermia or azoospermia with normal
karyotype. Azoospermic patients underwent testicular sperm extraction and aspiration
(TESE, TESA). Then ICSI was performed to patients who had testicular sperm or
ejeculat.
Results:
Fourty patients with AZF microdeletion were evaluated in this study. No
spermium could be found in 27 patients. Three of these patients had only AZFa
microdeletion, three had AZFb microdeletion, three had AZF (b+c), six had AZF
(a+b+c) and 12 patients had AZFc microdeletion. Only two of all patients achieved a
pregnancy and both had only AZFc microdeletion.
Conclusion:
AZFc microdeletions have a better prognosis for achieving spermium in
ejaculate or TESE, TESA materials.
Keywords
Y microdeletion, AZF, TESE, ICSI outcome
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© Copyright 2009 - Iranian Journal of Reproductive Medicine Alternative site location: http://www.ijrm.ir
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