International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 9, No. 3, 2011, pp. 229-238
Bioline Code: rm11035
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive Medicine, Vol. 9, No. 3, 2011, pp. 229-238
© Copyright 2011 Iranian Journal of Reproductive Medicine.
Cotherapy of Tiron and selenium against vanadium induced toxic effects in lactating rats|
Shrivastava, Sadhana; Joshi, Deepmala; Bhadauria, Monika; Shukla, Sangeeta & Mathur, Ramesh
Background: Vanadium is an important environmental and industrial pollutant. It has a status of reproductive toxicant and is reported to cross placental barrier.
Objective: The current study was performed to assess the therapeutic efficacy of Tiron and its combination with selenium against vanadium induced toxicity in lactating and suckling rats.
Materials and Methods: Rats were exposed to vanadium at a dose of 7.5 mg/kg/day (p.o.) for 20 days from 0 day of post partom (p.p.). Tiron (606 mg/kg/day, i.p.) and selenium (0.5 mg/kg/day, p.o.) were administered for 5 days on 21-25 day PP.
Results: Vanadium exposure decreased blood sugar level while serum transaminases and serum alkaline phosphatase showed increased values significantly (p≤0.01). Elevation in glycogen content of liver and kidney of suckling and kidney of lactating rats was found after toxicant administration. Toxicant intoxication increased the enzymatic activity of acid phosphatase in liver of suckling and lactating and kidney of suckling rats. On the contrary alkaline phosphatase and adenosine triphosphatase activities were inhibited significantly (p≤0.01) in all the organs. Lipid peroxidation was enhanced whereas glutathione was reduced significantly in liver of suckling and lactating rats (p≤0.01). Vanadium also caused histopathological lesions. Therapies of Tiron per se and Tiron along with selenium maintained almost all blood and tissue biochemical parameters towards normal. Tiron along with selenium reduced vanadium induced lesions in lactating and sucklings rats.
Conclusion: Tiron along with selenium is more effective than Tiron alone against vanadium induced toxic effect on lactating and suckling rats.
Vanadium, selenium, Suckling, lactating, Teratogenecity, Tiron
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