Background: Citrus aurantium
is a small citrus tree, with scented white flowers. The
C. aurantium is used in Asian herbal medicine primarily to treat digestive problems.
Objective: The goal of this study is to investigate the effect of
C. aurantium flower's aqueous extract on uterine contraction in presence of some known uterus stimulants.
Materials and Methods: In experimental study 30 virgin Wistar rats 200-300gr were obtained. After laparatomy, a piece of Uterus was dissected out and mounted in an organ bath (10ml) containing De Jalon (29°C) and contracted by KCl (60mM), oxytocin (10mU/ml) and barium chloride (4mM) then the effect of C. aurantium flower's aqueous extract (1-8 mg/ml) on the uterine contractions was investigated. Uterus was separately incubated with propranolol (1?M), naloxone (1?M) and the role of ß-adrenoceptors, opioid receptors were evaluated.
Results: Cumulative concentrations of the extract (1-8 mg/ml) decreased KCl, oxytocin and barium chloride induced uterine contractions, dose-dependently (p<0.001).
C. aurantium flower's aqueous extract was unaffected on incubation the tissue with propranolol and naloxone.
Conclusion: It seems that the extract induced antispasmodic effect mainly via calcium influx blockade. However, neither ß-adrenoceptors nor opioid receptors were involved. Since the extract has antispasmodic effect on uterus contraction therefore we can suggest that more study will be necessary to relief dysmenorrheal.
