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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 11, No. 1, 2013, pp. 1-10
Bioline Code: rm13001
Full paper language: English
Document type: Review Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 11, No. 1, 2013, pp. 1-10

 en Contribution of human oocyte architecture to success of in vitro maturation technology
Khalili, Mohammad Ali; Nottola, Stefania A; Shahedi, Abbas & Macchiarelli, Guido

Abstract

The use of ovarian stimulation for infertility treatment is associated with side effects of ovarian hyperstimulation syndrome (OHSS) and potential cancer risk. This is also true in high risk women such as those polycystic with ovary (PCO) and polycystic ovarian syndrome (PCOS). In vitro maturation (IVM) of oocytes was primarily developed to make IVF safe for women with PCO and at high risk of OHSS. The application of IVM of oocytes to assist clinical infertility treatment remains poor because of the reduced developmental competence of oocytes after IVM, despite several decades of research. Reduced meiotic maturation and fertilization rates, as well as low blastocyst production reveal short-term developmental insufficiency of oocytes when compared with in vivo-matured counterparts. In this review, the structural role of human oocytes, revealed by different technical approaches, to the success of IVM technology is highlighted.

Keywords
Human, Oocyte, In Vitro Oocyte Maturation Technique, Cell Morphology, Ultrastructure

 
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Alternative site location: http://www.ijrm.ir

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