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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 11, No. 8, 2013, pp. 659-664
Bioline Code: rm13083
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 11, No. 8, 2013, pp. 659-664

 en Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family
Shekouhi, Sahar; Baghbani, Fatemeh; Nazar-Abadi, Mohammad Hasanzadeh; Hamzehloie, Tayebeh; Abbaszadegan, Mohammad Reza; Saghafi, Nafiseh; Raoofian, Reza; Reza, Javad Zavar; Ahmadzadeh, Shahab; Tabatabaiefar, Mohammad Amin & Mojarrad, Majid

Abstract


Background: Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified.
Objective: In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA.
Materials and Methods: A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program.
Results: Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively.
Conclusion: Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene.

Keywords
X-linked; Recurrent spontaneous abortion; Linkage

 
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