International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 11, No. 12, 2013, pp. 983-988
Bioline Code: rm13124
Full paper language: English
Document type: Editorial
Document available free of charge
International Journal of Reproductive Medicine, Vol. 11, No. 12, 2013, pp. 983-988
© Iranian Journal of Reproductive Medicine
Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window|
Alizadeh, Zohreh; Faramarzi, Shamila; Saidijam, Massoud; Alizamir, Tahereh; Esna-Ashari, Farzaneh; Shabab, Nooshin & Sanoee, Marzieh Farimani
Background: HOXA11 and HOXA10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. The expression of these genes is decreased in women with myomas.
Objective: To determine whether myomectomy would reverse HOXA11 and HOXA10 expression, we evaluated the transcript levels of these genes in the endometria of patients before and after myomectomy.
Materials and Methods: Expression of HOXA11 and HOXA10 were examined prospectively during the midluteal phase in endometrium obtained from infertile women (n=12) with myoma before and three months after myomectomy. Endometrial HOXA11 and HOXA10 expression were evaluated using quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).
Results: Endometrial HOXA11 and HOXA10 mRNAs expression levels (normalized to 18SrRNA) were increased insignificantly in endometrium of patients after myomectomy (p=0.7 and p=0.15 respectively).
Conclusion: The results suggest that the alteration in expression pattern of these genes could not account for some aspects of fertility after myomectomy.
Myoma; Uterine myomectomy; HOXA11; HOXA10; Endometrium; Embryo Implantation
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