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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 12, No. 6, 2014, pp. 389-394
Bioline Code: rm14055
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 12, No. 6, 2014, pp. 389-394

 en Expression of Toll-like receptors 7-10 in human fallopian tubes
Ghasemi, Nasrin; Amjadi, Fatemehsadat; Salehi, Ensieh; Shakeri, Mojgan; Aflatoonian, Abbas & Aflatoonian, Reza

Abstract

Background: The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We and others have previously revealed that TLRs1-6 express in the female reproductive tract. However, more studies should be done to detect TLRs 7-10 in the female reproductive tract, especially in the fallopian tubes.
Objective: To examine the expression of TLRs7-10 in human fallopian tube tissue.
Materials and Methods: Using immunostaining techniques, distribution of TLR7-10 was studied in surgical sections from the uterine tubes, obtained from patients undergoing tubal ligation and hysterectomy for benign gynecological conditions. RT-PCR was used to show the existence of TLR7-10 genes in fallopian tube tissue.
Results: TLR7-10 proteins were detected in the fallopian tube epithelium, although the intensity of staining was not equal in cases. TLR7-10 genes were expressed in human fallopian tube tissue.
Conclusion: This study indicates that TLR7-10 is expressed in fallopian tubes tissues, and may play an important role in microbial recognition, and in host defense against ascending infection.

Keywords
Fallopian tube; Innate immunity; Toll like receptors (TLRs); Reproductive medicine

 
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Alternative site location: http://www.ijrm.ir

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