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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 12, No. 8, 2014, pp. 581-585
Bioline Code: rm14083
Full paper language: English
Document type: Case Report
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 12, No. 8, 2014, pp. 581-585

 en Robertsonian translocation between chromosomes (no.21/14) in relation to the history of spontaneous abortion in a family
Abadi, Mohammad Hasanzadeh-Nazar; Baghbani, Fatemeh; Namazi, Iman & Mirzaee, Salmeh

Abstract

Background: Approximately 205 million pregnancies occur each year in the worldwide. On the other hand, Spontaneous abortion has been reported in 15-20% of all diagnosed pregnancies. The most common cause of spontaneous abortion is chromosomal abnormalities of the embryo. Robertsonian translocation carriers specially 21-14 are the most common balanced rearrangement among the carrier couples with the history of spontaneous abortion. In order to search for balanced chromosomal rearrangement and cytogenetic disorders, 10 members of related family with consanguinity marriage with the history of recurrent miscarriage were assessed.
Case: Cytogenetic evaluation on the basis G-banding technique at high resolution was performed in 3 couples and their related family with the history of idiopathic RSA in order to postulate any balanced chromosomal rearrangement.
Conclusion: six members of them appeared with robertsonian balanced translocation between chromosome No.21 to No. 14 with the karyotype of 45, XX, t (14, 21) and 45, XY, t (14, 21), which this results are in agreement with several similar works which claimed that the risk of spontaneous abortion in couples with balanced chromosomal rearrangements is higher compared with general population. Considering to results of present study, it seems as if the cytogenetic analysis of couples with the history of recurrent abortions should be suggested compulsory to estimate the probable presence of any chromosomal rearrangement. This offer wills valuable information for genetic consulting.

Keywords
Spontaneous abortion; Balanced chromosomal rearrangement; Robertsonian translocation; Chromosomal abnormality

 
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