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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 13, No. 4, 2015, pp. 215-220
Bioline Code: rm15030
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 13, No. 4, 2015, pp. 215-220

 en SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique
Taghizadeh, Eskandar; Kalantar, Seyed Mehdi; Mahdian, Reza; Sheikhha, Mohammad Hasan; Farashahi-Yazd, Ehsan; Ghasemi, Saeed & Shahbazi, Zahra


Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.
Objective: Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique.
Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.
Results: We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).
Conclusion: These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.

SULF1 gene; Polymerase chain reaction; Restriction fragment length Polymorphysm; Single nucleotide polymorphism; Restriction endonucleases; rs6990375

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