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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 13, No. 4, 2015, pp. 221-226
Bioline Code: rm15031
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 13, No. 4, 2015, pp. 221-226

 en Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders
Yıldız, Mesut; Vural, Mehmet; Erdal, Mehmet Emin; Ay, Özlem İzci; Yılmaz, Şenay Görücü; Karababa, İbrahim Fatih & Selek, Salih


Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.
Objective: The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.
Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.
Results: Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.
Conclusion: These findings do not support a major role of DRD3, and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.

Cannabinoid receptor; Dopamine D3 receptor; Premenstrual syndrome; Genetic polymorphism

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