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Iranian Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 13, No. 5, 2015, pp. 251-262
Bioline Code: rm15036
Full paper language: English
Document type: Review Article
Document available free of charge

Iranian Journal of Reproductive Medicine, Vol. 13, No. 5, 2015, pp. 251-262

 en The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia
Nikuei, Pooneh; Malekzadeh, Kianoosh; Rajaei, Minoo; Nejatizadeh, Azim & Ghasemi, Nasrin

Abstract

Preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. Early diagnosis and management of disease could reduce its potential side effects. The vascular endothelial growth factor (VEGF) family including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endothelial cell proliferation and has basic role in vasculogenesis. VEGF and its tyrosine kinase receptors (Flt1 and KDR) are major factors for fetal and placental angiogenic development. Finding mechanisms involved in expression of angiogenic factors may lead to new prognostic and therapeutic points in management of preeclampsia. Recent researches, has shown capability of some anti-angiogenic factors as potential candidate to be used as early predictors for preeclampsia. Soluble fms-like tyrosin kinase-1 (sFlt1) is a truncated splice variant of the membrane-bound VEGF receptor Flt1, that is produced by the placenta and it can bind to angiogenic growth factors and neutraliz, their effects. It is also observed that the ratio of sFlt1 to placental growth factor is valuable as prognostic marker. In this review, VEGF family member’s role in angiogenesis is evaluated as biomarkers to be used for prediction of preeclampsia.

Keywords
Preeclampsia; Angiogenic proteins; Biomarker; Vascular endothelial growth factor (VEGF-A); Vascular endothelial growth factor receptor-1 (VEGFR-1)

 
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