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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 14, No. 1, 2016, pp. 9-14
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Bioline Code: rm16002
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 14, No. 1, 2016, pp. 9-14
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Nitric oxide donors improve the ovulation and pregnancy rates in anovulatory women with polycystic ovary syndrome treated with clomiphene citrate: A RCT
Mahran, Ahmad; Abdelmeged, Ayman; Shawki, Hossam; Moheyelden, Abdelrazek & Ahmed, Asmaa Mohamed
Abstract
Background: Clomiphene citrate (CC) is the first line agent used for ovulation
induction in patients with polycystic ovarian syndrome (PCOS). However, there is
marked discrepancy between the ovulation and pregnancy rates achieved, which
may be attributed to the undesirable effect of CC on cervical mucus and
endometrium.
Objective: The aim of this study was to evaluate the effect of Isosorbid monoitrate
(ISMN) as nitric oxide (NO) donors on the ovulation and pregnancy rates in an
ovulatory women with PCOS treated with CC.
Materials and Methods: Ninety patients with PCOS were randomly allocated into
three groups. Patients in group A) were treated with 100 mg CC for five days
starting from the fifth day of the cycle. Patients in group B) and C) received 10 mg
and 20 mg of ISMN respectively in addition to CC, applied vaginally till the
diagnosis of ovulation.
Results: There was a significant increase in the ovulation and pregnancy rates in the
patients treated with CC+ISMN as compared with patients treated with CC alone
(p< 0.001).
Conclusion: Concomitant use of NO with CC seems to improve the ovulation and
pregnancy rates in the patients with PCOS with no significant increase in side effects
as compared with CC alone.
Keywords
Polycystic ovary syndrome; Clomiphene citrate; Nitric oxide donors
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