Although the effectiveness of ginger as an antioxidant agent has been
exploited, little human research has been conducted on its activity on male
This study was designed to investigate the effects of ginger ( Zingiber officinale
) on sperm DNA fragmentation (SDF) in infertile men.
Materials and Methods:
This randomized double-blind, placebo-controlled trial
with a 1:1 allocation was performed on 100 infertility treatment candidates who
were admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran.
Patients were randomly assigned to receive one of two treatments: ginger and
placebo. Patients were given a 3-month oral treatment (members received capsules
containing 250 mg of ginger powder twice a day in ginger and a placebo in other
group). Before and after treatment, standardized semen samples were obtained to
determine sperm concentration, motility, and SDF according to World Health
There was no significant difference between two groups regarding SDF at
baseline (53.48. 95%CI: 37.95-69.02) in cases and (56.75, 95%CI: 40.01-73.5) in
controls. The average positive percentage of SDF in patients receiving ginger
(17.77, 95%CI: 6.16-29.39) was lower compared with placebo (40.54, 95%CI:
23.94-57.13) after three month of treatment (p=0.02). In multivariate analysis, SDF
was significantly lower in patients receiving ginger compared with placebo (mean
difference: 3.21, 95%CI: 0.78-5.63, p=0.009). There were no significant differences
between two groups regarding to semen parameters.
The present study has demonstrated that ginger in a controlled study of
efficacy was effective in decreasing SDF in infertile men.