Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure?: An RCT|
Salehpour, Saghar; Zamaniyan, Marzieh; Saharkhiz, Nasrin; modares, Shahrzad Zadeh; Hosieni, Sedighe; Seif, Samira; Malih, Narges; Rezapoor, Parinaz & Sohrabi, Mohammad-Reza
Background: Recurrent implantation failure is one of the most issues in IVF cycles.
Some researchers found that beneficial effects of endometrial Scratching in women
with recurrent implantation failure, while some authors demonstrated contrary results
Objective: The present study aimed to investigate the effect of intrauterine. Saline
infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo
transfer cycle, among patients with recurrent implantation failure.
Materials and Methods: In this clinical trial study 63 women undergoing assisted
reproductive technology were divided into two groups either local endometrial
injury by intrauterine saline infusion during day 3-5 of the ongoing controlled
ovarian stimulation cycle, or IVF protocol performed without any other intervention
in Taleghani Hospital, Tehran, Iran. The main outcome measure was clinical
Results: Patients who received intra uterine saline infusion (n=20), had significantly
lower clinical pregnancy numbers (1 vs. 9, p<0.05) and implantation rates (4.7% vs.
41.6%, p<0.05), compared to controls (n=39). However, there was no significant
difference in miscarriage rates (9.4% vs. 8.7%, p>0.05) and multiple pregnancy
numbers (1 vs. 3, p>0.05) between groups.
Conclusion: When intrauterine saline infusion as a form of endometrial injury is
performed during the ongoing IVF cycles it has negative effect on reproductive
outcomes among patients with recurrent implantation failure.
Artificial Insemination; Embryo implantation; Embryo Transfer; Fertilization in Vitro; Endometrium; Injuries; Pregnancy