International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 14, No. 10, 2016, pp. 625-628
Bioline Code: rm16080
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive Medicine, Vol. 14, No. 10, 2016, pp. 625-628
© Copyright 2016 - Iranian Journal of Reproductive Medicine
Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study|
Nazari, Leila; Salehpour, Saghar; Hoseini, Sedighe; Zadehmodarres, Shahrzad & Ajori, Ladan
Background: Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one.
Objective: This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients.
Materials and Methods: Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study. Intrauterine infusion of 0.5 ml of platelet-rich plasma that contained platelet 4-5 times more than peripheral blood sample was performed 48 hrs before blastocyst transfer.
Results: Eighteen participants were pregnant with one early miscarriage and one molar pregnancy. Sixteen clinical pregnancies were recorded and their pregnancies are ongoing.
Conclusion: According to this study, it seems that platelet-rich plasma is effective in improvement of pregnancy outcome in RIF patients.
Platelet-rich plasma; Implantation; Fertilization in Vitro; Pregnancy rate; Repeated implantation failure
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