International Journal of Reproductive Medicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 3, 2017, pp. 169-174
Bioline Code: rm17023
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive Medicine, Vol. 15, No. 3, 2017, pp. 169-174
© Copyright 2017 - Iranian Journal of Reproductive Medicine
Expression of placental growth factor mRNA in preeclampsia|
Nikuei, Pooneh; Rajaei, Minoo; Malekzadeh, Kianoosh; Nejatizadeh, Azim; Mohseni, Fatemeh; Poordarvishi, Fatemeh; Ghashghaeezadeh, Nasrin & Mohtarami, Mehrdad
Background: Preeclampsia (PE) is a serious complication of pregnancy with
hallmarks of incomplete placentation, placental ischemia and endothelial
dysfunction. Imbalance between vascular endothelial growth factor (VEGF),
placenta growth factor (PlGF) and their receptors play important role in
pathophysiology of PE.
Objective: This study was aimed to asses PlGF mRNA expression in placenta of
women affected with PE.
Material and Methods: In this cross-sectional study, expression of PlGF mRNA
was evaluated in 26 mild PE cases, 15 severe preeclamptic women and 20
normotensive controls. Patients were sub-classified as early onset PE (9) and late
onset (32). After RNA extraction, PlGF expression was quantified with qRT-PCR.
Results: The results of PlGF mRNA expression between mild-severe, and early-late
onset PE patients showed no statistically significant difference compared with the
control group (p=0.661, p=0.205 respectively).
Conclusion: Despite we found no distinct differential expression of PlGF mRNA in
placental tissue of PE patients compared with control women, but according to
decreased level of this angiogenic factor in PE even before clinical onset of the
disease, determining molecular mechanisms related to reduced secretion of PlGF
into the maternal circulation may be useful for future therapeutics.
Preeclampsia; Expression; Placental growth factor; Endothelial dysfunction
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