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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 15, No. 5, 2017, pp. 265-272
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Bioline Code: rm17036
Full paper language: English
Document type: Review Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 15, No. 5, 2017, pp. 265-272
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Protective effects of melatonin and ghrelin on spermatogenesis: A narrative review of the literature
Gholami, Mohammadreza; Ahmadi, Seyyed Amir Yasin; Abaszadeh, Abolfazl & Khaki, Arash
Abstract
Spermatocytogenesis starts from lumens of seminiferous cords and after migration
to the basal membrane ends to the lumens again. We attempt to review the protective
effects of melatonin and ghrelin on Spermatocytogenesis and in particular on
spermatogonial stem cells, as two rather newly-discovered hormones. Testicular
freezing prior to chemotherapy and radiotherapy is one of the ways of preserving
fertility in children with cancer. The freezing has two methods of slow-freezing
(cryopreservation) and rapid-freezing (vitrification). Administration of melatonin
can maintain the quality of the germ cells underwent such processes, as well as
ghrelin, can protect germ cells from the toxicities secondary to ischemic injuries,
and pathologic apoptosis. This review indicates that in vitro or in vivo
administration of melatonin or ghrelin, could be effective to preserve fertilization
and also they can be used in assisted reproductive technologies to improve the
quality of sperms. Future original studies should be propelled toward human studies,
of course with observing the ethics.
Keywords
Spermatogonia; Cryopreservation; Vitrification; Melatonin; Ghrelin.
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© Copyright 2017 - International Journal of Reproductive Medicine Alternative site location: http://www.ijrm.ir
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