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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 15, No. 6, 2017, pp. 375-382
Bioline Code: rm17049
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 15, No. 6, 2017, pp. 375-382

 en Polycystic ovary syndrome and circulating inflammatory markers
Zangeneh, Farideh Zafari; Naghizadeh, Mohammad Mehdi & Masoumi, Masoumeh


Background: Human and experimental studies suggest that the sympathetic regulatory drive in the ovary may be unbalanced (hyperactivity) in polycystic ovary syndrome (PCOS). Dysfunctional secretion of interleukin (IL) -1 (α & β) or related cytokines may thus be related to abnormal ovulation and luteinization.
Objective: The aim of this study was the evaluation of cytokines’ pattern in PCOS women and discussion about the explanation of cross-talk between two super systems: sympathetic and immune systems and explanation sympatho-excitation and relationship with interleukins.
Materials and Methods: In this study, 171 PCOS women aged between 20-40 years were studied. Their body mass index was <28. The patients were divided into two groups: study group (n=85, PCOS women) and control group (n=86 normal women). The blood sample was obtained on the 3rd day of menstruation cycle. IL-17, IL-1α, IL-1β, and Tumor necrosis factor-alpha (TNF-α) concentrations were determined in both groups.
Results: The median serum level of IL-1α in the PCOS group was higher than the control group (293.3 and 8.0, respectively, p<0.001). Also, the median serum level of IL-1β was higher than the control group (5.9 and 3.1 respectively). But the median serum of level IL-17 in women with PCOS was significantly lower than the control group (p<0.001).
Conclusion: Our results confirm that PCOS is a low-level chronic inflammation.

Polycystic ovary syndrome; IL1α-1β; IL-17A; Sympathetic nervous system

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