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Maternal serum uric acid level and maternal and neonatal complications in preeclamptic women: A cross-sectional study
Asgharnia, Maryam; Mirblouk, Fariba; Kazemi, Soudabeh; Pourmarzi, Davood; Keivani, Mina Mahdipour & Heirati, Seyedeh Fatemeh Dalil
Abstract
Background: Preeclampsia is associated with maternal and neonatal complications.
It has been indicated that increased uric acid might have a predictive role on
preeclampsia.
Objective: We aimed to investigate the relationship between the level of uric acid
with maternal and neonatal complications in women with preeclampsia.
Materials and Methods: In this cross-sectional study, 160 singleton preeclamptic
women at more than 28 wk gestational age were included. Hemoglobin, hematocrit,
platelet count, liver and uric acid tests, and maternal and neonatal complications
were assessed. The severity of preeclampsia, placental abruption, preterm labor,
thrombocytopenia, elevated alanine aminotransferase and aspartate aminotransferase
(ALT and AST), HELLP syndrome, eclampsia and required hospitalization in the
ICU was considered as the maternal complication. Fetal complications were: small
for gestational age (SGA), intrauterine fetal death, hospitalization in the neonatal
intensive care unit, and Apgar score <7 at five minutes.
Results: Of our participants, 38 women had severe preeclampsia (23.8%). The mean
level of uric acid in women with severe preeclampsia was significantly higher than
non-severe preeclampsia (p=0.031), also in those with an abnormal liver test
(p=0.009). The mean level of uric acid in women with preterm delivery was
significantly higher than women with term delivery (p=0.0001). Also, the level of
uric acid had no effect on neonatal hospitalization in neonate invasive care unit.
Based on logistic regression, the incidence of severe preeclampsia not affected by
decreased or increased serum levels of uric acid.
Conclusion: With higher level of uric acid in server preeclampsia we can expected
more complications such as hepatic dysfunction and preterm delivery. Thus serum
uric acid measurement can be helpful marker for severe preeclampsia.
Keywords
Pregnancy; High-risk; Preeclampsia; Uric acid; Pregnancy complications.
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