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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 17, No. 11, 2019, pp. 831-840
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Bioline Code: rm19086
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 17, No. 11, 2019, pp. 831-840
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Evaluation of vitamin D status, parathyroid hormone, and calcium among Iranian pregnant women with preeclampsia: A case-control study
Hamedanian, Laaya; Badehnoosh, Bita; Razavi-Khorasani, Niloofar; Mohammadpour, Zinat & Mozaffari-Khosravi, Hassan
Abstract
Background: Preeclampsia is considered as a serious life-threatening condition that could affect
both maternal and fetal outcome. Many studies have examined the association of nutritional
factors with the incidence of preeclampsia. However, little is known about the possible role of
vitamin D in the development of preeclampsia among the Iranian population.
Objective: The aim of the present study was to evaluate the association between vitamin D
status and preeclampsia.
Materials and Methods: A total of 120 pregnant women who were referred to Kamali and
Alborz General Hospital located in the Karaj City were enrolled in this study and categorized
into preeclamptic and control groups (n = 60/each). The clinical details of patients such as
demographic characteristics and laboratory findings were obtained from the patients. The
serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured.
Multivariate logistic regression analysis was used to assess for independent predictors of
preeclampsia.
Results: The mean age among pregnant women with preeclampsia and control group
were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among
the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the
control group (p < 0.001). The serum vitamin D levels were significantly lower in women with
preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between
vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for
confounding factors.
Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the
pregnant women diagnosed with preeclampsia compared to the healthy subjects. However,
no correlation was observed between the vitamin D status and the risk of preeclampsia
development.
Keywords
Preeclampsia; Vitamin D; 25-Hydroxyvitamin D; Pregnancy.
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© Copyright 2019 - Laaya Hamedanian et al. Alternative site location: http://www.ijrm.ir
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