The role of melatonin in polycystic ovary syndrome: A review|
Mojaverrostami, Sina; Asghari, Narjes; Khamisabadi, Mahsa & Khoei, Heidar Heidari
Background: Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder,
affecting approximately 20% of women within reproductive age. It is associated
with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility.
Melatonin is the main pineal gland hormone involved in the regulation of the circadian
rhythm. In recent years, it has been observed that a reduction in melatonin levels
of follicular fluid exists in PCOS patients. Melatonin receptors in the ovary and intrafollicular
fluid adjust sex steroid secretion at different phases of ovarian follicular
maturation. Moreover, melatonin is a strong antioxidant and an effective free radical
scavenger, which protects ovarian follicles during follicular maturation.
Objective: In this paper, we conducted a literature review and the summary of the
current research on the role of melatonin in PCOS.
Materials and Methods: Electronic databases including PubMed/MEDLINE, Web of
Science, Scopus, and Reaxys were searched from their inception to October 2018 using
the keywords “Melatonin” AND “Polycystic ovary syndrome” OR “PCOS.”
Results: Based on the data included in our review, it was found that the administration
of melatonin can improve the oocyte and embryo quality in PCOS patients. It may also
have beneficial effects in correcting the hormonal alterations in PCOS patients.
Conclusion: Since metabolic dysfunction is the major finding contributing to the
initiation of PCOS, melatonin can hinder this process via its improving effects on
Hyperandrogenism; Infertility; Melatonin; PCOS.