Role of latent female genital tuberculosis in recurrent early pregnancy loss: A retrospective analysis|
Bagchi, Bishista; Chatterjee, Siddhartha & Chowdhury, Rajib Gon
Background: Latent Female Genital tuberculosis (FGTB) or tubercular infestation
is prevalent in Southeast Asia and even the presence of tubercular bacilli in the
genital tract is becoming an important factor for reproductive failure. An immature
endometrium becomes non-receptive, preventing implantation or rejection of
implanted embryo in early months, resulting in recurrent pregnancy loss (RPL) in
association with other factors.
Objective: To detect the underlying causes of RPL in addition to the proven causes like
uterine cavity defects, thrombophilia, chromosomal abnormalities, etc.
Materials and Methods: 317 women with RPL, enrolled over a period of 60 months
( January 2014 to December 2018) conducted at Calcutta Fertility Mission in the present
study. They were grouped in A, B, and C and undergone routine tests for the same along
with the PCR test with an endometrial aspirate.
Results: Patients with only latent FGTB (Group A), patients with FGTB and associated
factors (Group B), and patients with other causes of RPL (other than latent FGTB) (Group
C) were34.4%, 42.3%, and 23.3% respectively. About 29.36%, 47.01%, and 21.62%of
the patients had achieved pregnancy in Group A, B, and C, respectively. The rate of
miscarriage was high in both Groups A and B, affected with latent FGTB, and live-birth
was higher (75%) in Group C that did not have tubercular involvement of the genital
Conclusion: The tubercular infestation or latent FGTB as per our study appears to be
a very important cause of RPL in patients with recurrent “unexplained” miscarriage. It
should be treated adequately at an early stage to prevent permanent damage to pelvic
organs and restore reproductive health in women.
Female genital tuberculosis; Recurrent pregnancy loss; Endometrium; Implantation.