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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 2, 2020, pp. 105-112
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Bioline Code: rm20012
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 18, No. 2, 2020, pp. 105-112
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Comparison of letrozole with gonadotropin-releasing hormone agonist in frozen embryo transfer after recurrent implantation failure: An RCT
Khadem Ghaebi, Nayere; Mahmoudiniya, Malihe; Najaf Najafi, Mona; Zohdi, Elnaz & Attaran, Matin
Abstract
Background: The use of frozen embryo transfer (FET) is increasing worldwide in
the treatment of infertility by in vitro fertilization. Different methods of endometrial
preparation for FET have been suggested.
Objective: The aim of this study was to compare the pregnancy outcomes
after treatment with letrozole and those after treatment with the combination of
gonadotropin-releasing hormone (GnRH) agonist and estradiol in FET.
Materials and Methods: This randomized controlled trial study was conducted on
142 infertile women with a history of previous FET failure. Participants were randomly
assigned to two groups (n = 71 each). The GnRH group received 500 μg of buserelin
plus 4mg estradiol (which increased to 8 mg if endometrial thickness was less
than 5 mm), and the letrozole group received 5 mg of letrozole plus 75 IU of
recombinant human follicle-stimulating hormone). At least two high-quality embryos
were transferred to each subject in both groups. The outcome measures were clinical
pregnancy rate and fetal heart rate detection.
Results: Subjects in the study groups had similar demographic characteristics and
baseline clinical condition. Mean endometrial thickness in the letrozole and GnRH
agonist groups were 8.90 ± 0.88 mm and 8.99 ± 0.85 mm, respectively (p = 0.57).
The number of positive results of the beta human chorionic gonadotropin test and
detection of fetal heartbeat were not significantly different between the groups (p >
0.05).
Conclusion: The administration of letrozole and GnRH may produce similar pregnancy
outcomes in FET.
Keywords
Letrozole; Fertilization in vitro; Pregnancy outcome.
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© Copyright 2020 - Khadem Ghaebi et al. Alternative site location: http://www.ijrm.ir
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