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Platelet-rich plasma in the management of Asherman’s syndrome: An RCT
Javaheri, Atiyeh; Kianfar, Katayoon; Pourmasumi, Soheila & Eftekhar, Maryam
Abstract
Background: Asherman’s syndrome (AS) is a rare reproductive abnormality, resulting
in endometrial collapse due to aggressive or recurrent endometritis and/or curettage.
Objective: We aimed to assess the effectiveness of using platelet-rich plasma (PRP) to
lower the recurrence rate of intrauterine adhesions (IUAs) following hysteroscopy.
Materials and Methods: In this non-randomized clinical trial, women aged 20-45 years with AS diagnosed by sonohysterography, 3D sonography, hysteroscopy,
or uterosalpingography between May 2018 and September 2018 were included.
Participants (n = 30) were divided into case and control groups. Following hysteroscopic
adhesiolysis, a Foley catheter was placed into the uterine cavity in all women. After two
days, the catheter was removed, and 1-mL PRP was injected into the uterine cavity of
women in the PRP (case) group, while the control received no PRP. All controls and
subjects underwent diagnostic hysteroscopy 8-10 weeks following the intervention to
assess the IUAs according to the American Society for Reproductive Medicine scoring
system.
Results: Our results did not reveal any significant difference in the menstrual pattern
of either the control or test groups before or after treatment (p = 0.2). Moreover, the
IUA stage in both studied groups before and after treatment was similar (p = 0.2). The
duration of menstrual bleeding in both studied groups before and after treatment was
also similar.
Conclusion: PRP cannot change the menstrual pattern or development of postsurgical
AS, as evaluated by follow-up hysteroscopy.
Keywords
Asherman’s syndrome; Platelet-rich plasma; Pregnancy rate.
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