International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 18, No. 3, 2020, pp. 201-208
Bioline Code: rm20025
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 18, No. 3, 2020, pp. 201-208
© Copyright 2020 - Taheripanah et al.
Effects of clomiphene citrate plus estradiol or progesterone on endometrial ultrastructure: An RCT|
Taheripanah, Robabeh; Kabir-Salmani, Maryam; Favayedi, Masoomeh; Zamaniyan, Marzieh; Malih, Narges & Taheripanah, Anahita
Background: Pinopods concentrations in endometrial surface is a marker of
implantation. Estradiol valerate (EV) was used to change the adverse effects of
Clomiphene Citrate (CC) on the endometrium.
Objective: The goal was to assess whether there is a significant difference in the
endometrial pinopods concentrations and other parameters after adding EV and
progesterone to higher doses of CC.
Materials and Methods: In this prospective randomized clinical trial, a total of 30
women who did not respond to 100 mg of CC from February 2016 to June 2016 were
evaluated. They were divided into three groups: group I) received 150 mg of CC alone,
group II) CC with EV, and group III) CC plus progesterone. On day 21 of the menstrual
cycle, endometrial biopsy, a blood sampling, and a scanning by electron microscopy
Results: On day 21 of the menstrual cycle, there was no significant difference in the
pinopods concentrations (p = 0.641) and serum estrogen levels (p = 0.276) between
groups. However, the Serum progesterone levels in group I was higher than the other
two groups (p = 0.007) in the same day.
Conclusion: Since the addition of EV and progesterone to higher dosages of CC did
not change the pinopods concentration and serum estrogen levels on day 21 of the
menstrual cycle, and the serum progesterone levels was higher in CC alone group (i.e.
group I) compared to other groups, it can be concluded that the anti-estrogenic effects
of CC just appear on the endometrium and not on the plasma levels.
Ovulation induction; Clomiphene; Estradiol; Progesterone; Electron microscopy; Endometrium.
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