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Prevalence of metabolic syndrome in four phenotypes of PCOS and its relationship with androgenic components among Iranian women: A cross-sectional study
Zaeemzadeh, Narges; Sadatmahalleh, Shahideh Jahanian; Ziaei, Saeideh; Kazemnejad, Anoshirvan; Mottaghi, Azadeh; Mohamadzadeh, Neda & Movahedinejad, Maryam
Abstract
Background: Polycystic ovary syndrome (PCOS) increases the risk of metabolic
syndrome (MetS). Insulin resistance (IR) plays a major role in the pathophysiology of both
PCOS and MetS.
Objective: This study was designed to compare the prevalence of MetS among different
phenotypes of PCOS and its relationship with androgenic components.
Materials and Methods: 182 participants eligible for this five-group comparative study
were selected by convenience sampling method. They were classified according to
the Rotterdam criteria: clinical and/or biochemical hyperandrogenism (H) + PCOS on
ultrasound (P) + ovulation disorders (O) (n = 41), clinical and/or biochemical H + PCOS on
P (n = 33), PCOS on P + O (n = 40), clinical and/or biochemical H + O (n = 37), and control
(without PCOS) (n = 31). MetS was measured based on the National Cholesterol Education
Program Adult Treatment Panel III criteria. Androgenic components included free-androgen-index (FAI), total-testosterone (TT) level and sex-hormone-binding-globulin
(SHBG).
Results: A significant difference was observed between the study groups in terms of
MetS prevalence (p = 0.01). In phenotype H+P+O, there was a statistically significant
positive association between TG and TT, and a significant negative association between
SBP and DBP with SHBG. In phenotype O+P, WC was inversely associated with SHBG.
In phenotype H+O, FBS and TG were positively associated with FAI but HDL was
inversely associated with FAI. Moreover, WC and DBP were positively associated with
TT in phenotype H+O. No associations were detected between MetS parameters and
androgenic components in other PCOS subjects (phenotype H+P) and in the control
group. TT was significantly higher in the PCOS group suffering from MetS (p = 0.04).
Conclusion: According to the research results, hyperandrogenic components are potent
predictors of metabolic disorders. Thus, we suggest that MetS screening is required for
the prevention of MetS and its related complications in PCOS women.
Keywords
Polycystic ovary syndrome; Metabolic syndrome; Hyperandrogenism.
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