|
International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 4, 2020, pp. 287-294
|
Bioline Code: rm20033
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
International Journal of Reproductive BioMedicine, Vol. 18, No. 4, 2020, pp. 287-294
en |
Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
Eftekhar, Maryam & Saeed, Lida
Abstract
Background: Aromatase inhibitors prevent the aromatization of androgens into
estrogens, which reduces the negative feedback of estrogen on the hypothalamicpituitary
axis. It is clear that increasing the secretion of follicle-stimulating hormones
results in an increased follicular growth.
Objective: This study aimed to evaluate the effect of adding letrozole to gonadotropin
on in vitro fertilization outcomes in normal responders.
Materials and Methods: In this randomized clinical trial, 100 normal responder women
candidate for controlled ovarian stimulation were randomly enrolled in two groups (n
= 50/each). In the case group letrozole was added to gonadotropin in the antagonist
protocol. The control group received the conventional antagonist protocol. The main
outcome was clinical and chemical pregnancy; and the second outcomes were the
number of mature oocytes, the fertilization rate, estradiol level, and the total dose of
gonadotropins.
Results: Basic clinical and demographic features were comparable between the
groups. Estradiol level on the day of human-chorionic-gonadotropin administration
and the total gonadotropin consumption were significantly higher in the control group
than the case group (p = 0.045). In addition, the number of MII oocytes was higher
(but not significantl) in the case group than the control group (p = 0.09). Moreover,
the endometrial thickness was significantly lower in the case group. There were no
significant differences in fertilization rate and chemical and clinical pregnancy rates
between the two groups.
Conclusion: Although adding letrozole to gonadotropin in normal responders reduces
the total dose of gonadotropin, it does not improve the pregnancy outcomes.
Keywords
Letrozole; Ovarian stimulation; Pregnancy.
|
|
© Copyright 2020 - Eftekhar et al. Alternative site location: http://www.ijrm.ir
|
|