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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 4, 2020, pp. 307-310
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Bioline Code: rm20035
Full paper language: English
Document type: Short Communication
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 18, No. 4, 2020, pp. 307-310
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Comparison of ovulation induction with letrozole plus dexamethasone and letrozole alone in infertile women with polycystic ovarian disease: An RCT
Farzaneh, Farahnaz & Afshar, Fatemeh
Abstract
Background: Infertility is characterized by the inability to obtain a successful pregnancy
after 6 months or more with unprotected and regular intercourse. In developing
countries, the incidence of infertility is 2%. The causes of infertility could be male factor
or female factor, or mixed factor.
Objective: This study was conducted with the aim of comparison the ovarian response
to letrozole alone and letrozole plus dexamethasone in infertile women with poly cystic
ovarian disease (PCOS).
Materials and Methods: This randomized clinical trial was conducted on 120 infertile
women with PCOS referred to Ali-Ebne-Abitaleb hospital, Zahedan, Iran from February
to August 2017 into two groups: group I received letrozole alone and group II
recived letrozole plus dexamethasone. The endometrial thickness, follicle diameter,
and ovulation were evaluated and compared by ultrasound on days 12 to 14.
Results: The mean thickness of endometrium was not different between two groups.
Pregnancy rate was 8% in letrozole group and 23% in Letrozole plus Dexamethasone
(p = 0.024). Also, the mean diameter of follicles in two groups were not statistically
significant.
Conclusion: Overall, this study showed that dexamethasone may increase pregnancy
rate.
Keywords
Letrozole; Dexamethasone; PCOS; Induction ovulation.
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© Copyright 2020 - Farzaneh et al. Alternative site location: http://www.ijrm.ir
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