|
International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 18, No. 8, 2020, pp. 605-610
|
Bioline Code: rm20065
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
International Journal of Reproductive BioMedicine, Vol. 18, No. 8, 2020, pp. 605-610
en |
Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study
Sylus, Angel Mercy; Nandeesha, Hanumanthappa & Chitra, Thiagaraju
Abstract
Background: Obesity, inflammation and alterations in matrix metalloproteinase-9
(MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary
syndrome (PCOS).
Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with
the increase in body mass index (BMI) in women with PCOS.
Materials and Methods: Sixty two infertile PCOS women were included in the study.
Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in
BMI.
Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was
significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP-9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and
negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative
correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was
also found in the PCOS subjects.
Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated
with NO levels and the duration of infertility.
Keywords
Body mass index; Interleukin-10; Nitric oxide; Matrix metalloproteinase-9.
|
|
© Copyright 2020 - International Journal of Reproductive BioMedicine Alternative site location: http://www.ijrm.ir
|
|