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Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review
Tezerjani, Masoud Dehghan & Kalantar, Seyed Mehdi
Abstract
Recent advances in human transcriptome have revealed the fundamental and
functional roles of long non-coding RNA in the susceptibility to diverse diseases
and pathological conditions. They participate in wide range of biological processes
such as the modulating of chromatin structure, transcription, translation, and post-translation
modification. In addition, based on their unique expression profiles and their
association with clinical abnormalities such as those of related to male reproductive
diseases, they can be used to develop therapeutic methods and biomarkers for
screening of the diseases. In this study, we will review the identified lncRNAs and
their molecular functions in the pathogenesis of male reproductive diseases such as
prostate cancer, benign prostatic hyperplasia, prostatitis, testicular cancer, varicocele,
and sperm abnormalities.
Keywords
Long noncoding RNA; Prostate cancer; Prostatic hyperplasia; Prostatitis; Varicocele; Sperm abnormalities.
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