en |
The comparison of predictive value of cervical length in singleton spontaneous preterm labor with in vitro fertilization pregnancies: A cohort study
Jafari, Razieh Mohammad; Zargar, Mahvash; Barati, Mojgan & Ershadian, Somayeh
Abstract
Background: Preterm labor (PTL) is one of the most important factors in neonatal
mortality. Some studies have revealed a reverse relationship between cervical length
(CL) and PTL, however, further evidence is needed to confirm it.
Objective: To investigate the predictive value of CL in spontaneous and in vitro
fertilization (IVF) pregnancies.
Materials and Methods: This prospective cohort study was performed on 154 pregnant
women from 16-26 wk of gestation with singleton fetus in spontaneous delivery (n = 77)
and IVF pregnancies (n = 77) and followed up until delivery. Women with multiple
pregnancy, placenta previa, cerclage, and congenital anomalies were excluded from
study. The cut-off determination was done according to the Roc analysis.
Results: The mean CL in term delivery and PTL groups were 37 ± 7 mm and 31 ± 6 mm,
respectively (p < 0.001). The frequency of PTL in spontaneous and IVF pregnancies
were 7.8% and 23.27%, respectively (p = 0.007). According to the Roc analysis, the best
cut-off for normal pregnancy was ≤ 36 mm with the negative predictive value of 97.9%,
the positive predictive value of 11.4%, sensitivity 83.3%, and specificity of 46.5%. While
for the IVF group, the cut off was ≤ 30 mm, with a negative predictive value of 88.4%,
positive predictive value of 57.8%, sensitivity of 63.2%, and specificity of 86%.
Conclusion: In this study, IVF had a significant direct correlation with PTL. CL also had
a significant indirect relationship with PTL.
Keywords
Cervix; IVF; Preterm delivery; PTL.
|