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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 2, 2021, pp. 181-190
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Bioline Code: rm21018
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 2, 2021, pp. 181-190
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Abnormal anti-Müllerian hormone level may be a trigger for breast cancer in young women: A case-control study
Jalaeefar, Amirmohsen; Moini, Ashraf; Eslami, Bita; Alipour, Sadaf; Shirkhoda, Mohammad; Aryan, Arvin; Mahmoodzadeh, Habibollah & Omranipour, Ramesh
Abstract
Background: Anti-Müllerian hormone (AMH) is a known sensitive biomarker for fertility
and ovarian reserve. The results of in vivo and human studies showed inconsistency
with respect to the relation between AMH and breast cancer.
Objective: To compare the AMH level of young Iranian women with early breast cancer
who have not received any treatment compared to that of healthy women.
Materials and Methods: In this case-control study, 58 breast cancer cases were
recruited from the breast oncology clinic of two university hospitals. They were
diagnosed with an in situ or invasive breast cancer before any anticancer treatment
between August 2018 and April 2019. Healthy controls (n = 58) were selected from
women referred to a gynecologic outpatient clinic without any symptoms of cancer or
infertility. AMH was measured by the AMH enzyme-linked immunosorbent assay kits
in one laboratory.
Results: Final analysis showed that the AMH means of case and control were not
statistically significant (3.36 ± 2.95 vs 3.13 ± 1.79). However, the lower and higher AMH
level categories are more prevalent in breast cancer compared to the control. Pearson’s
correlation test showed that the AMH level was negatively correlated with age (r = -0.44,
p< 0.001). The results of logistic regression analysis considering confounding factors
showed the positive association between breast cancer and lower (Odds Ratio [OR] =
5.98, p = 0.02) and higher quartile of AMH level (OR = 4.95, p = 0.01).
Conclusion: Our results suggest that abnormal AMH level is more frequent in
young breast cancer patients. Further investigation considering AMH determinants is
required.
Keywords
Anti-Müllerian hormone; Breast cancer; Biomarkers; Ovarian reserve.
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© Copyright 2021 - Jalaeefar et al. Alternative site location: http://www.ijrm.ir
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