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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 3, 2021, pp. 245-254
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Bioline Code: rm21024
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 3, 2021, pp. 245-254
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Reproductive toxicity potentials of methanolic extract of Portulaca oleracea in male rats: An experimental study
Okafor, Izuchukwu Azuka; Nnamah, Uchenna Somtochukwu; Ahiatrogah, Selasie; Serwaa, Dorcas & Nnaka, Jude
Abstract
Background: Purslane is an edible widely distributed shrub and one of the herbs used
in decoctions for the treatment of different ailments including infertility. However, there
is a shortage of evidence to validate its reproductive effects.
Objective: To investigate the effect of methanolic extract of Portulaca oleracea (MEPO)
on the reproductive system of male rats.
Materials and Methods: Fifteen 10-wk old male Wistar rats with an average weight
of 183 gr were randomly divided into three groups (n = 5/each). Group A (the control
group) received distilled water only; group B received 400 mg/kg MEPO; and group C
received 800 mg/kg MEPO for 14 days. The animals fasted overnight after the 14th day
of administration and euthanized by cervical dislocation. Blood samples, sperm, testes,
and epididymis were collected for serum hormones, sperm, and histological analyses.
Results: There was no significant change in the serum luteinizing hormone and
testosterone levels across all groups when compared to the control. However, group
C showed a significant increase (p = 0.020) in follicle-stimulating hormone levels when
compared to the control. There was a significant reduction (p = 0.006) in the sperm
count in group C when compared with the control group. There was also a significantly
reduced (p = 0.003) sperm motility in MEPO-treated groups compared to the control.
While the testis showed no abnormalities in its histoarchitecture across groups, the
epididymis showed some blood congestion in MEPO-treated groups.
Conclusion: Portulaca oleracea showed the ability to reduce sperm count and motility
at higher doses.
Keywords
Portulaca oleracea; Purslane; Testis; Epididymis; Rat; Sperm motility
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© Copyright 2021 - Okafor et al. Alternative site location: http://www.ijrm.ir
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