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Maternal thyroid function test level during the first trimester of pregnancy at a center Yazd, Iran: A cross-sectional study
Gholami, Somaye; Namiranian, Nasim; Shukohifar, Marzieh; Kalantari, Foroozandeh & Azizi, Reyhaneh
Abstract
Background: Thyroid dysfunction is associated with negative pregnancy outcomes.
There is a lack of reliable information on thyroid hormones in Iranian pregnant women,
especially in Yazd.
Objective: To determine the safe thyroid hormone levels in women of Yazd and also the
first trimester-specific reference ranges for serum thyroid-stimulating hormone (TSH),
thyroxine (T4), and triiodothyronine (T3).
Materials and Methods: In this cross-sectional study, the serum of 1,148 women in the
first trimester of pregnancy was analyzed. Thyroid function tests (TSH, T4, T3) were
measured through radioimmunoassay (RIA) [immunoradiometric (IRMA) for TSH]. The
study was conducted in Yazd, from September 2018 to November 2019. Reference
intervals were defined as the 5th, 50th, and 95th percentiles.
Results: The mean age of the participants was 28.78 (± 5.86 yr) (range: 15-45 yr). The
thyroid hormones reference intervals in the first trimester were TSH (0.2-3.8 mIU/l), T4
(7.45-12.75, 𝜇g/dl), and T3 (100-217 ng/dl).
Conclusion: The results of the present study determined a local thyroid function
measurement in the first trimester of pregnancy at a center of Yazd, Iran. This could
facilitate the decision-making of maternal TSH level during the first trimester of
pregnancy.
Keywords
First pregnancy trimester; Thyrotropin; Thyroxine; Triiodothyronine.
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