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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 4, 2021, pp. 339-346
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Bioline Code: rm21032
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 4, 2021, pp. 339-346
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Role of hyaluronic acid intrauterine injection in the prevention of Asherman’s syndrome in women undergoing uterine septum resection: An RCT
Ghanadzadeh Tafti, Seiede Zahra; Javaheri, Atiye; Dehghani Firoozabadi, Razieh; Kabirpour Ashkezar, Samane & Falahzadeh Abarghouei, Hossein
Abstract
Background: Adhesion due to intrauterine surgery such as septal resection associated
with damaged endometrium can increase the risk of Asherman’s syndrome. The main
goal of treatment in this syndrome is to repair the damaged endometrium for creating
a physiological pregnancy.
Objective: To investigate the effect of intrauterine injection of hyaluronic acid on the
prevention of Asherman’s syndrome in women undergoing uterine septum resection.
Materials and Methods: In this double-blind randomized clinical trial, 65 women
undergoing the uterine septum resection were divided into two groups; the case group
(n = 34) and the control group (n = 31). Immediately after the septal resection with
a resectoscope, 1cc of hyaluronic acid gel in the case group and 1cc normal saline
solution as a placebo in the control group was injected into the uterine cavity. After
two months, existence of intrauterine adhesions in the both groups was examined by
the hysteroscope and assessment of menstrual patterns, according to the American
Society for Reproductive Medicine criteria.
Results: Our results showed that after intervention, the incidence of Asherman’s
syndrome in the control group was higher than the case group (p = 0.012). In the case
group, only four women had poor adhesion (Asherman’s syndrome) at the end of the
study, while the rest of them were free of any adhesions in the uterine cavity. In the
control group, however, only 19 were free of intrauterine adhesions and 12 had mild
symptoms.
Conclusion: The results of the study exhibited the hyaluronic acid capacity to reduce
the risk of Asherman’s syndrome in women with endometrial damage following a septal
resection surgery.
Keywords
Asherman’s syndrome; Septum; Uterine; Hyaluronic acid; Resection.
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© Copyright 2021 - Ghanadzadeh Tafti et al. Alternative site location: http://www.ijrm.ir
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