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Improved hormonal and oxidative changes by Royal Jelly in the rat model of PCOS: An experimental study
Khazaei, Fatemeh; Ghanbari, Elham & Khazaei, Mozafar
Abstract
Background: Polycystic ovarian syndrome (PCOS) is an endocrine and complex
metabolic disorder, associated with anovulation, changes in sex hormone,
biochemical factors, and ovarian tissue. Royal Jelly (RJ) has antioxidant and antiinflammatory
properties.
Objective: To examine the therapeutic effect of RJ on PCOS-related hormonal and
biochemical changes in a rat model of PCOS.
Materials and Methods: In this experimental study, 42 female Wistar rats (weighing
180–200 gr, aged 10–12 wk) were divided into six groups (n = 7/each): control;
PCOS; RJ 100 mg/kg; RJ 200 mg/kg; PCOS + RJ 100 mg/kg; and PCOS + RJ
200 mg/kg. After 21 days, the animals were weighed and dissected. The serums
were used for nitric oxide (NO) and ferric-reducing antioxidant power (FRAP) assay
and estradiol and progesterone measurements. The ovaries were assessed for
histological changes.
Results: PCOS increased estradiol and NO levels, and decreased progesterone
and FRAP levels. In PCOS + RJ groups, the progesterone (p = 0.01) and FRAP
levels (p ≤ 0.001) increased and the estradiol and NO (p ≤ 0.001) levels decreased
significantly. Moreover, the number of mature follicles (p = 0.01) and corpus luteum
increased (p ≤ 0.001), and ovarian and uterus weight deceased significantly
(p ≤ 0.001).
Conclusion: RJ improved estradiol, progesterone, FRAP, and NO levels, and ovarian
structure in the rat model of PCOS.
Keywords
Royal Jelly; Polycystic ovary syndrome; Ovary; Sex hormone.
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