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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433 EISSN: 1680-6433
Vol. 19, No. 9, 2021, pp. 773-780
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Bioline Code: rm21080
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Reproductive BioMedicine, Vol. 19, No. 9, 2021, pp. 773-780
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Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT
Hosseinisadat, Robabe; Saeed, Lida; Ashourzadeh, Sareh; Heidari, Sedigheh Safar & Habibzadeh, Victoria
Abstract
Background: Several mediators play an important role in implantation. One of these
mediators is human chorionic gonadotropin (HCG).
Objective: To evaluate the effects of HCG intrauterine injection on the day of oocyte
retrieval on the result of assisted reproductive techniques (ART).
Materials and Methods: In this randomized clinical trial study, 126 women who were
referred to Afzalipour Infertility Center between December 2018 to December 2019
undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled
and assigned to two groups of: a case (n = 62) and a control group (n = 64). The
protocols for both groups were the same; except that the case group was injected
with the protocols for both groups were the same, except that the case group was
injected with 1000 IU of HCG into uterine cavity following the oocyte puncture, while
no medication was administered to the control group. The implantation rate, chemical
pregnancy, clinical pregnancy, and abortion rates were compared between the two
groups.
Results: Positive chemical pregnancy was seen in 15 (27.3%) cases of the case group
and 14 (25.5%) of the control group. No significant difference was seen in the chemical
and clinical pregnancy rates between the groups. The abortion rate was higher in the
control group but that was not significant.
Conclusion: A 1000 IU of HCG intrauterine injection after oocyte retrieval does not
improve implantation, chemical or clinical pregnancy rates in ART cycles. Further
studies are needed to clearly understand the role of HCG intrauterine injection in the
day of oocyte retrieval in ART outcomes.
Keywords
Oocyte retrieval; Chorionic gonadotropin; Pregnancy; Assisted reproductive techniques.
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