en |
Co-administration of GnRH agonists with vaginal progesterone compared to vaginal progesterone in luteal phase support of the frozen-thawed embryo transfer cycle: An RCT
Zareii, Afsoon; Davoodi, Sara; Alborzi, Mahshid; Moghadam, Marzieh Eslami & Askary, Elham
Abstract
Background: Since progesterone alone does not seem to be enough for luteal
phase support (LPS), especially in frozen embryo transfer (FET) cycles, so
gonadotropin-releasing hormone agonist (GnRH-a) is suggested as an adjuvant
therapy in combination with progesterone for LPS.
Objective: To evaluate the effects of the administration of GnRH-a with vaginal
progesterone compared to vaginal progesterone alone in luteal phase support of the
frozen-thawed embryo transfer cycles.
Materials and Methods: In this randomized controlled clinical trial, 240 infertile women
who were candidates for FET were evaluated into two groups (n = 120/each). Group
I received 400 mg vaginal progesterone twice a day from the time of transfer. The
second group received vaginal progesterone and also 0.1 mg diphereline on days 0,
3, and 6 of FET for LPS. Finally, the clinical and ongoing pregnancy rates, and the
implantation, and spontaneous abortion rates were compared in two groups.
Results:Results showed that there was no significant difference between the mean age
of women and the duration of infertility (p = 0.78, p = 0.58, respectively). There were no
significant differences between groups in the terms of implantation and spontaneous
abortion rates (p = 0.19, p = 0.31, respectively). However, in terms of clinical and ongoing
pregnancy rates, the significant differences were seen between groups (p = 0.008 and
p = 0.005, respectively).
Conclusion: Co-administration of GnRH-a and vaginal progesterone in LPS may be
superior to vaginal progesterone alone in women who underwent a frozen-selected
embryo transfer cycle.
Keywords
Luteal phase; Fertilization in vitro; Embryo transfer.
|