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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 1680-6433
Vol. 20, No. 2, 2022, pp. 101-110
Bioline Code: rm22013
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 20, No. 2, 2022, pp. 101-110

 en Basella alba check for this species in other resources , Grewia asiatica check for this species in other resources , Solanum nigrum check for this species in other resources and Ficus carica check for this species in other resources fruit extracts ameliorate the testicular histopathology induced by CCl4 exposure in albino mice: An experimental study
Ahmad, Syeda Nadia; Ahmad, Khawaja Raees; Abdullah, Usma; Malik, Fiza; Ali, Rabiyah; Amir-ud-din, Umara; Kanwal, Muhammad Ali & Inayat, Iram

Abstract

Background: Carbon tetrachloride (CCl4) is extensively used in various industries and induces oxidative stress in humans. Unfortunately, it is one of the neglected potent male reproductive toxicants.
Objective: The present research reports the testicular histopathology of CCl4 and ameliorations by four medicinal fruit pulp extracts (FPEs) in mice.
Materials and Methods: Sixty male albino mice were divided into six groups (10/group) as per the following: 1. Vehicle control (Vc); 2. CCl4 (C); 3-6. CCl4+Basella alba (CBa), CCl4+Solanum nigrum (CSn), CCl4+Ficus carica (CFc) and CCl4+Grewia asiatica (CGa). Except for the control group, CCl4 (0.1 mL of 0.2 mL kg−1) was given to the animals in corn oil. The four plant extracts (0.1 mL each) were respectively given to the relevant FPE group animals for the next five consecutive days, while the animals in the Vc and CCl4 groups received water instead of FPE.
Results: The CCl4 exposure led to various histometric and histological alterations (loss of interstitial tissue and various dislodged tailless spermatids with enlarged heads) that were recovered in all except Solanum nigrum FPE mice post-treatment. The micrometric data of testicular sections also indicated significant decline in the number of spermatogonia, while the cross-sectional area of the sperm heads remained significantly higher in the CSn and C groups.
Conclusion: Except for Solanum nigrum, the three FPEs, especially Ficus carica, showed rehabilitative properties against CCl4 exposure-related modifications in testicular histopathologies.

Keywords
Basella alba; Grewia asiatica; Solanum nigrum; Ficus carica; testis.

 
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