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Rwanda Medical Journal
Rwanda Health Communication Center - Rwanda Biomedical Center (RHCC - RBC)
ISSN: 2079-097X(print); 2410-8626(online)
Vol. 75, No. 2, 2018, pp. 5-8
Bioline Code: rw18005
Full paper language: English
Document type: Research Article
Document available free of charge

Rwanda Medical Journal, Vol. 75, No. 2, 2018, pp. 5-8

 en Antibiotic Resistance in Children with Bacteremia Admitted in the Largest Tertiary Hospital in Rwanda
Ishimwe, E. & Rogo, T.

Abstract

Background: Bacteremia is a common cause of morbidity and mortality in children. The causative bacteria and antibiotic sensitivities differ from region to region. Timely administration of effective antibiotics can be life-saving for septic patients, therefore it is important for clinicians to be aware of their local epidemiology when selecting empiric antibiotics for the treatment of bacteremia.

Objectives: The goal of this study was to describe the microbiology and antibiotic resistance patterns of bacteremia in the pediatric department of the University Teaching Hospital of Kigali (UTHK).

Methods: This was a retrospective descriptive study conducted from 1st January 2015 to 31st December 2015. All admitted children with a positive blood culture were included in the study.

Results: Eighty children were identified with positive blood cultures during the period of the study. The most commonly isolated bacteria were Klebsiella check for this species in other resources species (30%, 24/80), Staphylococcus aureus check for this species in other resources (27.5%, 22/80), and Escherichia coli check for this species in other resources (22.5%, 18/80). In terms of resistance patterns, 60.0% of S. aureus was resistant to oxacillin. Among Klebsiella species, 33.3% were resistant to cefotaxime, 77.3% to gentamicin, and 42.8% to ciprofloxacin. There was 100% resistance to ampicillin.

Conclusion: Klebsiella species, S. aureus, and E. coli account for 80% of the cases of bacteremia. Use of ampicillin combined with gentamicin or cefotaxime for empiric treatment of bacterial sepsis provides poor coverage in this pediatric department. Epidemiological surveillance must continue to track changes in antibiotic susceptibility patterns.

Keywords
Bacteremia; Children; antibacterial drug resistance

 
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