Rwanda Medical Journal
Rwanda Health Communication Center - Rwanda Biomedical Center (RHCC - RBC)
Vol. 76, No. 2, 2019, pp. 1-5
Bioline Code: rw19009
Full paper language: English
Document type: Research Article
Document available free of charge
Rwanda Medical Journal, Vol. 76, No. 2, 2019, pp. 1-5
© Copyright 2019 - The Author(s)
Cholesterol lowering effects of Acacia nilotica subalata in Normal and Type 2 Diabetic Male Rats|
Niyodusenga, A.; Bukachi, F. O. & Kiama, T. N.
OBJECTIVE: To investigate the effects of Acacia nilotica subalata on plasma lipids in normal and type 2 diabetic male rats.
METHODS: Diabetes was induced in 18 out of 30 rats. The rats were in five groups: Group A normal control, Group B
diabetic control, Group C diabetic rats treated with Acacia nilotica subalata, Group D normal rats treated with Acacia
nilotica subalata and Group E diabetic rats receiving metformin. Blood glucose was measured with a glucometer. Lipids
were assayed by colorimetric methods. Data were expressed as mean ± standard error of mean and analyzed using
analysis of variance. Results were considered statistically significant if p < 0.05.
RESULTS: Acacia nilotica subalata and metformin decreased total cholesterol in Groups C and E compared to diabetic
control Group B (109.05 ± 9.134 and 90.69 ± 6.838 vs 153.89 ± 18. 829 mg/dl, p < 0.05). Acacia n. subalata and metformin
in Groups C and E significantly decreased low density lipoproteins (LDL) compared to diabetic control Group B (59.62 ±
6.532 and 42.32 ± 4.844 vs 105.56 ± 15.14 mg/dl, p < 0.05). Acacia nilotica subalata leaf extract may be considered
beneficial against hyperlipidemia induced by diabetes mellitus.
Acacia nilotica subalata, lipids, diabetes
Alternative site location: http://www.rwandamedicaljournal.org