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Rwanda Medical Journal
Rwanda Health Communication Center - Rwanda Biomedical Center (RHCC - RBC)
ISSN: 2079-097X
EISSN: 2410-8626
Vol. 76, No. 2, 2019, pp. 1-5
Bioline Code: rw19009
Full paper language: English
Document type: Research Article
Document available free of charge

Rwanda Medical Journal, Vol. 76, No. 2, 2019, pp. 1-5

 en Cholesterol lowering effects of Acacia nilotica subalata check for this species in other resources in Normal and Type 2 Diabetic Male Rats
Niyodusenga, A.; Bukachi, F. O. & Kiama, T. N.

Abstract

OBJECTIVE: To investigate the effects of Acacia nilotica subalata on plasma lipids in normal and type 2 diabetic male rats.
METHODS: Diabetes was induced in 18 out of 30 rats. The rats were in five groups: Group A normal control, Group B diabetic control, Group C diabetic rats treated with Acacia nilotica subalata, Group D normal rats treated with Acacia nilotica subalata and Group E diabetic rats receiving metformin. Blood glucose was measured with a glucometer. Lipids were assayed by colorimetric methods. Data were expressed as mean ± standard error of mean and analyzed using analysis of variance. Results were considered statistically significant if p < 0.05.
RESULTS: Acacia nilotica subalata and metformin decreased total cholesterol in Groups C and E compared to diabetic control Group B (109.05 ± 9.134 and 90.69 ± 6.838 vs 153.89 ± 18. 829 mg/dl, p < 0.05). Acacia n. subalata and metformin in Groups C and E significantly decreased low density lipoproteins (LDL) compared to diabetic control Group B (59.62 ± 6.532 and 42.32 ± 4.844 vs 105.56 ± 15.14 mg/dl, p < 0.05). Acacia nilotica subalata leaf extract may be considered beneficial against hyperlipidemia induced by diabetes mellitus.

Keywords
Acacia nilotica subalata, lipids, diabetes

 
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