Capecitabine Induced Hand-Foot Syndrome—A Case Report

Hand and foot syndrome (HFS) is a dose limiting dermatological toxic reaction of some chemotherapy agents like Capecitabine. Though not being life threatening, patient’s quality of life is compromised secondary to this syndrome. Early detection, dose reduction and interruption of the causative agent have been found to be key in management of HFS. We report a case of a 74-year-old female patient diagnosed with a metastatic rectal adenocarcinoma who received capecitabine as her management, while on treatment she developed signs and symptoms consistent with HFS. The chemotherapy agent was interrupted, and emollients were given to her as management.

Keywords
Cancer; Capecitabine; Colorectal; 5-Fluorouracil; Hand-Food Syndrome; Chemotherapy; Side Effects