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Analysis of short-term quality of life in post-surgical androgen deprivation therapy in advanced prostate cancer: a comparison of bilateral sub-capsular orchidectomy and bilateral total orchidectomy Arogundade, A. K.; Ajape, A. A.; Popoola, A. A.; Abiola, O. O. & Biliaminu, S. A. Abstract INTRODUCTION: The use of Androgen Deprivation Therapy (ADT) in treating advanced prostate cancer poses a host of challenges that can affect the health-related quality of life (HRQoL) of these patients. Previous studies have demonstrated the poor quality of life (QoL) of patients after ADT; however, there is a scarcity of literature that compares HRQoL following bilateral subcapsular orchidectomy (BSCO) and bilateral total orchidectomy (BTO) in sub-Saharan Africa. This study aimed to compare the HRQoL of patients with advanced prostate cancer following treatment with BSCO and BTO. METHODS: A randomized, single-blind study concerning 64 patients with advanced prostate cancer; the subjects were randomized into BTO and BSCO treatment groups. The study was conducted over a period of ten months at a tertiary hospital situated in the North-central zone of Nigeria. Structured and validated instruments (FACT-PI and Karnofsky) were used to assess HRQoL during patient follow-up visits over a period of six months to obtain data regarding HRQoL and patient satisfaction. Statistical analysis using a chi-squared test and paired t-test were done to allow the comparison of HRQoL assessment scores and patients’ satisfaction ratings between the two groups. RESULTS: The mean age of the subjects was 71.63   7.56 years and 70.06   8.79 years for the BTO and BSCO group respectively (p = 0.449). Also, the mean Gleason’s score was 7.44 vs. 7.31 respectively (p =0.714). Health-Related QoL assessment with FACT-PI and Karnofsky showed significantly better outcomes after BSCO (p < 0.001). Only 17% of the participants had psychological compromise after ADT. CONCLUSION: The two techniques of orchidectomy differ significantly in their short term QoL response to treatment; BSCO was associated with better patient outcomes compared to BTO. Keywords Advanced Prostate Cancer; Androgen Deprivation Therapy; Subcapsular Orchidectomy; Total Orchidectomy; Quality of Life

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