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International Journal of Environment Science and Technology
Center for Environment and Energy Research and Studies (CEERS)
ISSN: 1735-1472 EISSN: 1735-1472
Vol. 11, No. 3, 2014, pp. 765-774
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Bioline Code: st14076
Full paper language: English
Document type: Research Article
Document available free of charge
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International Journal of Environment Science and Technology, Vol. 11, No. 3, 2014, pp. 765-774
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Toxicity, biochemical and clastogenic response of chlorpyrifos and carbendazim in milkfish Chanos chanos
Palanikumar, L.; Kumaraguru, A. K.; Ramakritinan, C. M. & Anand, M.
Abstract
Carbendazim and Chlorpyrifos are some of the
most widespread environmental contaminants of major
concern to human and animal reproductive health. Acute
toxicity test results for pesticides were evaluated by the
Probit analysis method and 96 h LC50 values for C. chanos
exposed to chlorpyrifos was 3.73 and 11.5 μg l-1 for
carbendazim. Chlorpyrifos and carbendazim significantly
decreased total protein, catalase, glutathione S-transferase
and acetyl choline esterase and induced lipid peroxidation.
Maximum effects of protein, catalase, lipid peroxidation,
acetyl choline esterase and glutathione s-transferase were
obtained in response to 23.68 μg l-1 of chlorpyrifos and
43.68 μg l-1 of carbendazim. Micronuclei assay results
have shown increased abnormality with increasing doses of
chlorpyrifos and carbendazim. Maximum increasing in
micronuclei was observed in chlorpyrifos exposed
C. chanos. This study showed that chlorpyrifos and carbendazim
induced alterations in the activity of antioxidant
enzymes and could induce clastogenicity.
Keywords
Antioxidants; Biochemical effects; Lethal concentration; Clastogenicity; Toxicity
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