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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 1, No. 1, 2004, pp. 55-62
Bioline Code: tc04006
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 1, No. 1, 2004, pp. 55-62

 en Research Paper-ANTITRICHOMONAL ACTIVITY OF 1,3-DIARYL-2-PROPEN-1-ONES ON TRICHOMONAS GALLINAE
A.O.Oyedapo, V. O. Makanju, C. O. Adewunmi, E.O.Iwalewa, and T. K. Adenowo

Abstract

1,3-diaryl-2-propen-1-ones were synthesized by the Claisen - Schmidt condensation method. T. gallinae parasites isolated from domestic pigeon were cultured in vitro. The in vitro susceptibility of T. gallinae was evaluated in multi-well plates at 37oC. Four of the synthetic compounds produced significant antitrichomonal activity against T. gallinae. The minimal lethal concentrations (MLCs) (produced by) 2'-hydroxy-4-methoxychalcone, 2'-hydroxy-2,4'-dimethoxychalcone, 2'-hydroxy-4-chlorochalcone, 3,4,4'-Trimethoxychalcone and 4-hydroxcychalcone were 100.0, 0.78, 50.0, 50.0 and 3.13 μg/ml respectively. The results indicate that 2'-hydroxy-2,4'-dimethoxychalcone and 3 other synthetic 1,3-diaryl-2-propen-1-ones possess potent antitrichomonal activity against T. gallinae. However, the studies on cytotoxicity effect showed that all the active chalcones demonstrated a very low haemagglutination titre values ranging between 0.57 -4.06 suggesting their low toxicity profile.

Keywords
Trichomonas gallinae, 1,3-diaryl-2-propen-1-ones, in vitro activity

 
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