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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 1, 2005, pp. 25-30
Bioline Code: tc05005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 1, 2005, pp. 25-30

 en Research Paper - CARDIOVASCULAR PROPERTIES OF AQUEOUS EXTRACT FROM Tapinanthus dodoneifolius check for this species in other resources DC DANSER.
Sylvin Ouédraogo, Aristide Traoré, N. Soméa, M. Lompo, Pierre I. Guissou, Christa Schott Bernard Bucher, Ramaroson Andriantsitohain

Abstract

Aqueous extracts of Tapinanthus dodoneifolius check for this species in other resources DC Danser. (Loranthaceae) (AETD) were investigated for cardiovascular activities on isolated rat aorta and heart. AETD did not affect heart rate but significantly enhanced heart contraction force and relaxation capacity. AETD (0.001-1mg/ml) elicited a dose-dependent relaxation on arteries which was previously contracted with phenylephrine [10-6M] (rat aorta). AETD induces relaxation in endothelium dependent manner. When Indomethacin failed to inhibit AETD vasodilatory activity, in the presence of L-NAME, the vasodilatory activity of AETD was completely abolished. These results suggest a cardiotropic activity without any tachycardia as a side effect for AETD. However, AETD elicited vasodilatory activity which involved NO from endothelium.

Keywords
Tapinanthus dodoneifolius , endothelium , vasodilator , rat.

 
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