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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 1, 2005, pp. 62-69
Bioline Code: tc05008
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 1, 2005, pp. 62-69

 en Research Paper - ANTI-NOCICEPTIVE ACTIVITY OF HYGROPHILA AURICULATA (SCHUM) HEINE
P.Shanmugasundaram and S. Venkataraman

Abstract

Hygrophila auriculata check for this species in other resources (Schum) Heine (syn) Asteracantha longifolia check for this species in other resources Nees, Acanthaceae was described in ayurvedic literature as Ikshura, Ikshugandha, and Kokilasha. The plant was extensively used in traditional system of medicine for various ailments like rheumatism, inflammation, jaundice, hepatic obstruction, pain, etc. The aqueous extract of aerial parts (HAA) and root(HAR) were screened for its anti-nociceptive property using both chemical and thermal methods of nociception in mice. In chemical method acetic acid writhing test and in thermal methods hot plate and tail flick tests were performed. Both the extracts at doses 100 and 200 mg/kg/p.o inhibited the abdominal constrictions induced by acetic acid and also increased the pain threshold of mice towards the thermal source in a dose dependent manner. The activity exhibited by the extracts was comparable to that of the standard drug aspirin (100 mg/kg/p.o). From the results it was concluded that both extracts exhibited anti-nociceptive activity by central and peripheral mechanism(s).

Keywords
Hygrophila auriculata, Asteracantha longifolia, Anti-nociceptive, Writhing, Hot plate, Tail flick test.

 
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