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African Journal of Traditional, Complementary and Alternative Medicines
African Ethnomedicines Network
ISSN: 0189-6016
Vol. 2, No. 2, 2005, pp. 94-101
Bioline Code: tc05011
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Traditional, Complementary and Alternative Medicines, Vol. 2, No. 2, 2005, pp. 94-101

 en Research Paper - ANTIHYPERGLYCEMIC EFFECT OF Bridelia ndellensis check for this species in other resources ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
S.D. Sokeng, B. Rokeya, M. Mostafa, N. Nahar, M. Mosihuzzaman, L. Ali, P. Kamtchouing

Abstract

The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis check for this species in other resources stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of B. ndellensis had no hypoglycemic effect in type 1 diabetic rats in fasting and postprandial glucose load conditions and, in type 2 diabetic rats in fasting condition. However, the extract, and its ethyl acetate and dichloromethane fractions significantly lowered blood glucose levels in type 2 diabetic rats when fed simultaneously with glucose. The active principles responsible for the antihyperglycaemic effect are concentrated in the ethyl acetate and dichloromethane fractions of the extract.

Keywords
Bridelia ndellensis; hypoglycemic effect; Streptozotocin; diabetes; rats

 
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